抗腫瘤藥物可注射植入型水凝膠是一種用于腫瘤局部用藥的新型控釋系統(tǒng)。根據(jù)凝膠材料的不同以及各個(gè)實(shí)驗(yàn)室的具體條件，對(duì)該系統(tǒng)的藥理學(xué)評(píng)價(jià)方法有許多種。這些方法大致分為3類，包括生物相容性（安全性）評(píng)價(jià)、細(xì)胞毒性（藥效學(xué)）評(píng)價(jià)和藥動(dòng)學(xué)評(píng)價(jià)。綜述該系統(tǒng)藥理學(xué)評(píng)價(jià)方法學(xué)研究的近況，為進(jìn)一步研究和應(yīng)用提供參考。

The injectable implant hydrogel formulated antineoplastic agents exhibits a new delivery system for controlling to release in localized cancer therapy. According to the differences of gel materials and specific conditions in each laboratory, many evaluative methods for pharmacology are designed to the system. The methods can be approximately divided into three classes, biocompatible (security), cytotoxic (pharmacodynamics), and pharmacokinetic evaluations. The updated evaluative methods have been reviewed in this paper.

國家高技術(shù)研究發(fā)展“863”計(jì)劃（2009AA03Z313）