目的 觀察黃芪桂枝五物湯（浸膏）長期用藥對大鼠所產生的毒性反應。方法 連續(xù)給藥13周，試驗期間對大鼠的外觀、行為、體質量以及攝食等各項指標進行觀察檢測，并分別于給藥結束和恢復期結束進行血液學、血液生化學以及病理組織學檢查。結果 在黃芪桂枝五物湯（浸膏）給藥期間、給藥結束后以及恢復期，大鼠體質量、攝食、血液學、血液生化學和病理組織學等均未見毒理學意義的異常改變。結論 在本實驗條件下，黃芪桂枝五物湯（浸膏）24.0 g/(kg·d)（相當于臨床擬用日劑量109倍）為無毒反應劑量，表明該藥物具有相當大的安全范圍。

Objective To observe the toxic reaction of Huangqi Guizhi Wuwu Decoction on rats by long-term drug toxicity. Methods During the experiment, certain index of appearance, behavior, weight, and food intake were detected after successive administration for 13 weeks, and then, the hematology, blood-biochemics, and pathohistology in end administration period and recovery period were examined, respectively. Results Huangqi Guizhi Wuwu Decoction has no toxicological abnormal changes of weight, food intake, hematology, blood-biochemics, and pathohistology during administration end administration, and convalescent periods. Conclusion In the situation of this experiment, 24.0 g/(kg·d) (109 times dosage as much as that of clinical daily dose) of Huangqi Guizhi Wuwu Decoction is the non-toxic reaction dosage, which indicates that the drug has a sizable margin of safety.