目的 觀察丹參注射液、鹽酸左氧氟沙星注射液分別溶于5%葡萄糖注射液中不溶性微粒隨溶液pH值的改變而變化的情況。方法 利用微粒分析儀測(cè)定2種注射液分別與5%葡萄糖注射液的混合溶液及混合溶液隨pH值變化的微粒數(shù)。結(jié)果 與5%葡萄糖注射液混合后，在pH值較低時(shí)，丹參注射液的不溶性微粒明顯增加，鹽酸左氧氟沙星注射液的不溶性微粒增加不明顯。結(jié)論 丹參注射液不宜與其他藥物在同一容器中混合使用，不宜與較低pH值的葡萄糖注射液配伍；鹽酸左氧氟沙星注射液可與5%葡萄糖注射液配伍使用。

Objective To observe the insoluble particles variation of Levofloxacin Hydrochloride and Danshen Injection dissolved in 5% glucose injection, respectively, with the changing of pH value. Methods Using particle analyzer to determine the quantity of insoluble particles in the mixture of the two injections in 5% glucose injection, and also test the amount variation of insoluble particles with the changing of pH value. Results Mixed with 5% glucose injection, when pH value is lower, the amount of insoluble particles was significantly increased in Danshen Injection. On the other hand, there was no significant increase of insoluble particles in Levofloxacin Hydrochloric Injection. Conclusion Danshen Injection should not be mixed with other drugs in use, or mixed with glucose injection in the lower pH value; while Levofloxacin Hydrochloride Injection can be used with 5% glucose injection.