對近年國內外文獻中有關口服緩釋制劑體外溶出度測定的試驗方法和條件、體內評價的相關方法、體內外相關性研究進行了綜述。根據藥物的不同性質選擇盡可能接近體內環(huán)境的試驗方法，建立較好的體內外相關性，對口服緩釋制劑的研究具有重要意義。

To summarize all current literatures about the methods and test factors of dissolution and the evaluation of in vivo-in vitro correlation of sustained release oral dosage forms. According to the different nature of drugs, selecting the method could create a better in vivo condition and establish a better in vivo-in vitro correlation, which is important for the research on sustained release.

國家重點基礎研究發(fā)展計劃項目（2010CB735602）