對近年國內(nèi)外文獻(xiàn)中有關(guān)口服緩釋制劑體外溶出度測定的試驗方法和條件、體內(nèi)評價的相關(guān)方法、體內(nèi)外相關(guān)性研究進(jìn)行了綜述。根據(jù)藥物的不同性質(zhì)選擇盡可能接近體內(nèi)環(huán)境的試驗方法，建立較好的體內(nèi)外相關(guān)性，對口服緩釋制劑的研究具有重要意義。

To summarize all current literatures about the methods and test factors of dissolution and the evaluation of in vivo-in vitro correlation of sustained release oral dosage forms. According to the different nature of drugs, selecting the method could create a better in vivo condition and establish a better in vivo-in vitro correlation, which is important for the research on sustained release.

國家重點基礎(chǔ)研究發(fā)展計劃項目（2010CB735602）