目的 制備吲達(dá)帕胺微孔滲透泵片劑并研究其體外釋藥機(jī)制。方法 通過外觀觀察，測定不同衣膜、片芯、介質(zhì)等條件變化時(shí)的體外釋放度，考察其釋藥機(jī)制。結(jié)果 吲達(dá)帕胺微孔滲透泵片體外釋藥行為符合零級(jí)釋藥模型；不同衣膜、片芯和滲透壓介質(zhì)對(duì)藥物釋放有顯著影響；釋放介質(zhì)的pH值、溶出方法和轉(zhuǎn)速對(duì)藥物釋放無顯著影響。結(jié)論 該片劑的釋藥動(dòng)力主要為衣膜內(nèi)外的滲透壓差，藥物在滲透壓驅(qū)動(dòng)下經(jīng)微孔釋藥。

Objective To prepare Indapamide Microporous Osmotic Pump Tablets (INDP MPOPT) and to study their in vitro release mechanism. Methods The in vitro release was determined with different coat films, tablet cores, release medium, and other changes in conditions, and the mechanism of release was studied. Results The in vitro release behavior of INDP MPOPT complied with zero order release rule. Different clothes film, cores, and osmotic pressures had significant influence on drug release. While the pH value of dissolution medium, dissolution method, and rotation speed had less effect. Conclusion The release kinetics derives from the difference of the osmotic pressure across the membrance and drug release is through the micropores in the coat film.

國家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃項(xiàng)目（2010CB735602）