目的 探討健胃消食口崩片的藥理作用并與原劑型健胃消食片進(jìn)行藥效比較。方法 采用生大黃和利血平造成脾虛動(dòng)物模型，觀察健胃消食口崩片對(duì)脾虛動(dòng)物胃排空、小腸推進(jìn)運(yùn)動(dòng)、血清淀粉酶活力及胃液分泌等的影響。結(jié)果 健胃消食口崩片具有加快脾虛小鼠胃排空和小腸推進(jìn)運(yùn)動(dòng)，提高脾虛小鼠血清淀粉酶活力，提高脾虛小鼠胸腺系數(shù)和體質(zhì)量增加，延長(zhǎng)冰浴中小鼠游泳時(shí)間，促進(jìn)大鼠胃液分泌及胃酸排出等作用。結(jié)論 健胃消食口崩片可以有效改善動(dòng)物脾虛和消化不良癥狀，與原劑型療效相當(dāng)。

Objective To dicuss the pharmacological effects of Jianwei Xiaoshi Orally Disintegrating Tablets (JXODTs) and to compare the potency between Jianwei Xiaoshi Pills (JXPs) and JXODTs. Methods Animal model of spleen deficiency was established using rhubarb and Reserpine and the effects of JXODTs on gastric emptying, small intestine movement, serum amylase activity, and secretion of gastric juice were observed. Results JXODTs have the effects on accelerating gastric emptying and intestinal propulsion in mice spleen campaign to raise serum amylase deficiency, increasing spleen weight and thymus weight coefficients, extending swimming time of mice in an ice bath, promoting the gastric acid secretion and excretion of rats and so on. Conclusion JXODTs could better improve the state of animal spleen deficiency and indigestion, with the considerable effect of the original formulation.

江西省科技廳學(xué)術(shù)帶頭人培養(yǎng)計(jì)劃（2009DD00400）