目的 研究紅甜菜提取物對人宮頸癌HeLa細胞增殖和對荷瘤小鼠腫瘤生長的抑制作用。方法 采用細胞計數(shù)法觀察紅甜菜提取物對HeLa細胞的抑制作用，在人宮頸癌荷瘤鼠模型上觀察紅甜菜提取物對腫瘤生長的抑制作用，并用病理切片觀察瘤體細胞變化。結(jié)果 甜菜提取物對人宮頸癌HeLa細胞具有抑制作用，并具有劑量–時間依賴關(guān)系。荷瘤鼠動物實驗表明，紅甜菜提取物對裸鼠腫瘤生長也具有抑制作用，劑量為20 mg/d時抑瘤率為40%；攝入紅甜菜提取物組的裸鼠瘤體細胞出現(xiàn)壞死。結(jié)論 紅甜菜提取物對HeLa細胞的生長和對荷瘤裸鼠腫瘤生長具有抑制作用。

Objective To study the effects of red beet extract on human cervical HeLa cell proliferation and tumor growth in tumor-bearing mice. Methods The inhebition of red beet extract on Hela cell proliferation was determined by cell counting assay; Human cervical carcinoma HeLa cells were treated with red beet extract to detect the inhibition on the tumor growth of human cervical carcinoma HeLa cells in nude mice; The morphogeny of tumor cells was observed with a pathological section. Results The inhibition of red beet extract on HeLa cells was in a time- and dose-dependent manner; The red beet extract could inhibit the growth of HeLa cells in nude mice, the tumor-inhibitary rate (20 mg/d) was 40% for HeLa cells transplanted tumors; There was cell necrosis of the tumor in the groups fed with red beet extract. Conclusion The red beet extract could inhibit the growth of HeLa cells in vitro and the tumor growth in tumor-bearing mice.

新疆維吾爾自治區(qū)教育廳項目（XJEDU2008120）