目的 觀察骨新康對卵巢切除致大鼠骨質(zhì)疏松癥的治療作用。方法 選用SD雌性大鼠，隨機(jī)分為7組，每組12只，一組切去腹腔中少量脂肪作為假手術(shù)組，其余各組大鼠切除雙側(cè)卵巢，3個(gè)月后各組干預(yù)給藥，8周后測定各組股骨骨密度、骨生物力學(xué)指標(biāo)、骨顯微結(jié)構(gòu)，以及大鼠血清生化指標(biāo)。結(jié)果 骨新康具有增加骨密度、改善骨生物力學(xué)指標(biāo)以及具有性激素和促性腺激素樣作用。結(jié)論 該藥物具有抗大鼠骨質(zhì)疏松癥的作用。

Objective To investigate the effects of Guxinkang on osteoporosis in rats after ovariectomy (OVX). Methods SD female rats were randomly divided into seven groups with 12 in each group. The control group by cutting adipose tissue was Sham group, while the rats in other groups received bilateral OVX. After three months of surgery, Guxinkang was given to the rats for extra two months. The levels of bone density, bone biomechanics, blood calcium, blood phosphorate, and bone microstructure were observed in each group. Results Compared with the model group, Guxinkang could significantly increase the bone density, bone biomechanics, blood calcium, and the microstructure of bone trabecular width with hormone and gonadotropin-like action. Conclusion Guxinkang has a distinct preventive and effect on osteoporosis of rats.