基因治療藥物已成為當(dāng)今生物技術(shù)藥物研發(fā)的重點(diǎn)，而腺病毒是目前臨床基因治療較常選用的載體系統(tǒng)。它們?cè)诎l(fā)揮治療作用的同時(shí)，亦會(huì)引起機(jī)體出現(xiàn)毒性反應(yīng)。從腺病毒載體及相應(yīng)藥物引發(fā)的毒性反應(yīng)，固有免疫及獲得性免疫系統(tǒng)活化等方面對(duì)它們的毒性及其機(jī)制進(jìn)行總結(jié)。

Gene therapy drugs have become a key of exploitation for biotechnology-derived pharmaceuticals, and adenovirus vectors are common used to mediate gene therapy in clinic. They could induce toxicity reaction accompanied with their therapeutic effect simultaneously. This review will focus on the toxicity reaction and activation of innate and acquired immune system induced by adenovirus vectors and the related drugs to elucidate their toxicity and the related mechanism.

上海市科委2010年度實(shí)驗(yàn)動(dòng)物項(xiàng)目（10140901000）