液質(zhì)聯(lián)用技術(shù)以其高分離能力、高分辨率和專屬性強的優(yōu)勢，在藥物分析等方面得到廣泛的應(yīng)用。主要從串聯(lián)四極桿質(zhì)譜儀、四極離子阱質(zhì)譜儀、四極桿-飛行時間質(zhì)譜儀方面總結(jié)近年來液質(zhì)聯(lián)用技術(shù)在藥物有關(guān)物質(zhì)分析方面的應(yīng)用。

Liquid chromatography-mass spectrometry is regarded as an important technology for many advantages such as high separating efficiency, good sensitivity, and strong specificity. So it is widely used in analysis of drugs and metabolites, chemical medicine mixed illegally in Chinese medicine and drug residues. This paper briefly reviewed its application in drug related substances analysis from Quadrupole Mass Spectrometer, Quadrupole Ion Trap Mass Spectrometer, and Quadrupole-Time of Flight Mass Spectrometer.