環(huán)糊精包合技術(shù)和緩控釋技術(shù)是發(fā)展較快的釋藥技術(shù)，分子模擬技術(shù)在這兩種釋藥技術(shù)中的應(yīng)用也越來(lái)越多。簡(jiǎn)述環(huán)糊精包合技術(shù)和緩控釋釋藥技術(shù)的優(yōu)點(diǎn)、影響因素和釋藥原理，介紹幾種重要的分子模擬技術(shù)在環(huán)糊精包合技術(shù)和緩控釋釋藥技術(shù)中的應(yīng)用，并給出了分子模擬技術(shù)在具體應(yīng)用中的力場(chǎng)及模擬的條件，分析分子模擬技術(shù)的在環(huán)糊精包合技術(shù)和緩控釋技術(shù)中應(yīng)用的優(yōu)點(diǎn)和難點(diǎn)，展望分子模擬在其應(yīng)用中的前景，指出分子模擬技術(shù)有望成為研究釋藥技術(shù)的一種常規(guī)項(xiàng)的工具。

In recently year, technology of cyclodextrin inclusion and controlled release drug delivery systems have been developed at top speed, especially, the research of drug delivery technology by using molecular dynamics simulation as well as has grown rapidly. This review describes the advantages and influencing factors about the technology of cyclodextrin inclusion and controlled release drug delivery, introduces the methods of the molecular dynamics simulation and system of field force applied in those researches, evaluates of the status of their application. Based on those, author points out the outlook in the future study.

國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃項(xiàng)目（2010CB735602）；國(guó)家重大新藥創(chuàng)制專項(xiàng)（2011ZX09401-009，2010ZX09401-307-1-1）