目的 觀察清肺消炎丸對(duì)9種肺炎常見(jiàn)病原菌的體外抗菌作用。方法 采用瓊脂稀釋法，測(cè)定清肺消炎丸對(duì)9種藥敏質(zhì)控菌株的最低抑菌濃度（MIC）及最低殺菌濃度（MBC）。結(jié)果 清肺消炎丸對(duì)肺炎鏈球菌、化膿性鏈球菌、金黃色葡萄球菌、流感嗜血桿菌的MIC分別為6.25、25、25、50 mg/mL，相應(yīng)的MBC分別為12.5、25、50、50 mg/mL；對(duì)大腸桿菌、銅綠假單胞菌、肺炎克雷伯菌、變形桿菌及白色念珠菌均無(wú)明顯體外抑菌活性。結(jié)論 清肺消炎丸對(duì)肺炎鏈球菌、化膿性鏈球菌、金黃色葡萄球菌、流感嗜血桿菌具有體外抗菌作用，其中對(duì)鏈球菌的抗菌活性較高。

Objective To study the antibacterial effect of Qingfei Xiaoyan Pills. Methods By using test agar plates serial dilution method, the minimum inhibition concentration (MIC) and minimal bactericidal concentration (MBC) of different dilution degrees of Qingfei Xiaoyan Pills on Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia, Streptococcus pneumoniae, Escherichia coli, Proteusbacillus vulgaris, Haemophilus influenza, Streptococcus pyogeones, and Canidia albicans were determined. Results The MICs of Qingfei Xiaoyan Pills to Streptococcus pneumoniae, Streptococcus pyogeones, Staphylococcus aureus, and Haemophilus influenza were 6.25, 25, 25 and 50 mg/mL, respectively, while the MBCs were 12.5, 25, 50 and 50 mg/mL, respectively. Conclusion Qingfei Xiaoyan Pills could effectively inhibit Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogeones and Haemophilus influenza. Among them, Qingfei Xiaoyan Pills are more effective for Streptococcus.

國(guó)家自然科學(xué)基金資助項(xiàng)目（21002052）；天津市應(yīng)用基礎(chǔ)及前沿技術(shù)研究計(jì)劃（10JCYBJC14300）