目的 測定蒙花苷的溶解度及油水分配系數，為藥物成藥性評價及劑型設計提供依據。方法 采用HPLC法測定蒙花苷在不同有機溶劑及不同pH值緩沖鹽溶液中的平衡溶解度，并測定蒙花苷在高分子材料和表面活性劑中的溶解度；利用Molinspiration軟件對蒙花苷的油水分配系數進行預測，并采用搖瓶-HPLC法測定藥物在正辛醇-水、正辛醇-緩沖液體系中的表觀油水分配系數。結果 蒙花苷在水中的平衡溶解度為0.059 μg/mL，在堿性溶液中的溶解度有所增加；高分子材料和表面活性劑均可增加蒙花苷的溶解度，其中HP-β-CD的增溶作用最強，可增加214.6倍；l g蒙花苷在正辛醇-水、正辛醇-緩沖鹽溶液中的P值在0.50～1.04，與計算機預測值0.513一致。結論 蒙花苷不溶于水，脂溶性差，通過添加輔料，其溶解性有所提高。

Objective To establish a method for determination of solubility and oil-water partition coefficient of linarin, and to provide the basis for drug evaluation and dosage form design. Methods Equilibrium solubilities were determined by HPLC method in different organic solvents and different pH buffer solution systems; Also the solubilities of linarin in certain macromolecules and surfactant were measured; Molinspiration software was used to forecast the oil-water partition coefficient of linarin, and the partition coefficients of linarin in n-octanol-water/buffer solution systems were measured by shake flask-HPLC method. Results The equilibrium solubility of linarin in water was 0.059 μg/mL, which was lower than that in alkaline solution; Certain macromolecules and surfactant could increase the solubility of linarin, especially HP-β-CD with 214.6-fold increase; The octanol-water partition coefficient of linarin was between 0.50 and 1.04, consistent with the computer predicted 0.513. Conclusion Linarin is insoluble in water, and poor fat-soluble, but its solubility could be improved by adding accessories.