[關(guān)鍵詞]
[摘要]
喹諾酮類抗菌藥抗菌譜廣,在臨床上廣泛應(yīng)用于各種感染的治療。喹諾酮類藥物可通過阻斷拓撲酶的生理功能繼而干擾細菌的復(fù)制,從而起到抗菌的作用。也正是由于其廣泛應(yīng)用,近年來此類藥物的耐藥現(xiàn)象嚴重,且機制多樣。綜述了喹諾酮類藥物的作用機制、耐藥機制及其研究進展。
[Key word]
[Abstract]
Quinolones have potential and broad antimicrobial activity on gram-positive and -negative bacteria in clinic, respectively. They could interfere the duplication of bacteria by blocking the physiologic function of DNA gyrase and DNA topoisomerase IV. So quinolones have been used worldwide against a variety of infections. As a result of their frequent use, bacterial resistance to quinolones has gradually developed and limited their therapeutic efficacy in infections. This article reviews the antibacterial and resistance mechanisms of quinolone based on the recent research advances.
[中圖分類號]
[基金項目]
江蘇省省級科技創(chuàng)新與成果轉(zhuǎn)化專項引導(dǎo)資金項目(BE2008672)