藥物是否安全和有效是藥物研發(fā)成功與否的決定性因素。就藥物研發(fā)的整個流程而言，毒性是終止藥物研發(fā)的重要原因之一。藥物毒理學研究貫穿于新藥發(fā)現階段、臨床前安全性評價和上市后跟蹤監(jiān)督的全過程，因此藥物的毒理學研究至關重要。簡要綜述了藥物毒理學研究過程中所涉及的技術方法以及研究新動向，并主要介紹了組學技術的發(fā)展。

If the drug is safe and effective is the decisive factor to determine whether the drug development is successful or not. As far as the entire drug development process is concerned, toxicity is one important reason for the termination of drug development process. Studies on drug toxicology are throughout the entire process of drug discovery stage, preclinical safety evaluation, and after-sale track supervision, as a result the drug toxicology studies is critical. This article briefly summarized the technology, methods, and new research trends involved in drug toxicology studies, and introduced the development of omics technology.

“重大新藥創(chuàng)制”科技重大專項“十二五”計劃（2012ZX09505001-001）