目的 建立安多霖膠囊內(nèi)容物的紅外光譜和HPLC指紋圖譜，考察噴霧干燥與微波干燥對安多霖膠囊內(nèi)容物的影響。方法 分別對安多霖配方提取液選擇噴霧干燥、微波干燥兩種方法，制備8批供試品，繪制8批粉體的紅外光譜圖，采用高效液相色譜法，梯度洗脫繪制不同粉體溶液的HPLC指紋圖譜，比較不同干燥方法所得粉體的圖譜，評價不同干燥工藝的優(yōu)劣。結(jié)果 安多霖膠囊配方提取液經(jīng)噴霧干燥和微波干燥后，其紅外光譜和HPLC指紋圖譜極其相似，不同干燥工藝沒有引起安多霖膠囊物質(zhì)基礎(chǔ)的改變。結(jié)論 不同干燥工藝所得安多霖膠囊內(nèi)容物的物質(zhì)種類和總量極其相似，兩種干燥方法均可應(yīng)用于安多霖膠囊配方提取液的干燥。

Objective To establish infrared (IR) spectrum and HPLC fingerprint for the content of Anduolin Capsules (AC) and to investigate the effect of spray drying and microwave drying technologies on the content of AC. Methods Spray drying and microwave drying were used on AC preparation. Eight batches of AC powder were prepared, and the IR spectrograms were drawn. The HPLC fingerprint of different powder solutions was drawn using gradient elution, and the spectra of powders dried by various technologies were compared and evaluated. Results The IR spectrum and HPLC fingerprint of extracting solution from AC dried by various technologies were very similar, and the various drying technologies did not change the material basis in content of AC. Conclusion The content of AC dried by various technologies is extremely similar in material type and amount, and the two drying methods could be applied in AC extract.

福建省自然科學(xué)基金計劃項(xiàng)目（2009J01116）；福建省衛(wèi)生廳青年科研項(xiàng)目（2009-1-38）；福建省醫(yī)學(xué)科學(xué)研究院院立項(xiàng)目（2008-03）