目的 優(yōu)選通脈養(yǎng)心方的提取工藝。方法 使用氯仿誘發(fā)小鼠室顫模型和大鼠離體胸主動脈血管環(huán)試驗(yàn)結(jié)果結(jié)合甘草酸含量作為指標(biāo)，通過正交試驗(yàn)優(yōu)化通脈養(yǎng)心方提取工藝，并進(jìn)行驗(yàn)證。結(jié)果 確定最優(yōu)提取工藝為60%乙醇提取2次，第一次8倍量水提取1.5 h，第二次6倍量水提取1 h。結(jié)論 工藝優(yōu)化后的通脈養(yǎng)心方具有良好藥理活性，呈現(xiàn)量–效關(guān)系。

Objective To optimize extraction technology of Tongmai Yangxin prescription. Methods Animal arrhythmia on mice by chloroform and isolated thoracic aortic ring of rats to observe effects of pharmacological activity and contents of glycyrrhizic acid were used to optimization and verify the extraction process of Tongmai Yangxin prescription. Results Optimum extraction conditions were as follows: heating refluxing extracted 2 times with the amount of 60% ethanol for 8 times 1.5 hours and 6 times 1 hour. Conclusion Tongmai Yangxin prescription in the optimized extraction technology with significant pharmacological activity, showing the dose-effect relationship.