[關(guān)鍵詞]
[摘要]
越來(lái)越多的研究表明,雷帕霉素作為一種傳統(tǒng)的抗生素,表現(xiàn)出很強(qiáng)的抗老化作用,通過(guò)阻斷哺乳動(dòng)物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR),影響了多種基本的細(xì)胞周期,細(xì)胞的生長(zhǎng)和增殖,蛋白質(zhì)合成和細(xì)胞自噬過(guò)程,從而為神經(jīng)退行性疾病模型提供神經(jīng)保護(hù)作用,包括帕金森病、阿爾茨海默病、亨廷頓病等。對(duì)近期關(guān)于雷帕霉素神經(jīng)保護(hù)作用的研究成果予以綜述。
[Key word]
[Abstract]
In recent years, more and more studies indicate that Rapamycin (RAPA) as a traditional antibiotic that exerts strong anti-ageing effects in several species. By inhibiting the activity of mammalian target of Rapamycin (mTOR), RAPA influences a variety of essential cellular processes, such as cell growth and proliferation, protein synthesis, and cell autophagy. Thus, it could provide neuroprotection in several experimental models for neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and so on. The molecular mechanisms underlying the neuroprotective effects of Rapamycin in recent studies were reviewed.
[中圖分類(lèi)號(hào)]
[基金項(xiàng)目]