目的 觀察靜脈注射三乙醇胺后SD大鼠的組織病理學(xué)改變及其可逆性。方法 60只SD大鼠，隨機分為對照組和300 mg/kg劑量組，連續(xù)30 d給藥和恢復(fù)4周，分別進行大體解剖和組織病理學(xué)檢查。結(jié)果 連續(xù)給藥30 d，SD大鼠肝細(xì)胞嗜酸性變，腎髓質(zhì)腎小管上皮細(xì)胞變性，脾小體生發(fā)中心增大，白髓邊緣帶增寬，淋巴結(jié)內(nèi)淋巴濾泡數(shù)量增多，生發(fā)中心增大；恢復(fù)4周，肝臟、脾臟和淋巴結(jié)病變恢復(fù)不明顯。結(jié)論 靜脈注射一定劑量的三乙醇胺，對SD大鼠肝臟、腎臟、脾臟和淋巴結(jié)有一定的損傷作用，其中，腎臟的損傷可逆，脾臟、淋巴結(jié)和肝臟的損傷有一定程度的恢復(fù)。

Objective To observe the histopathological change of SD rats after iv administration with trolamine and its recoverability. Methods Sixty rats were divided into control group and rolamine group (300 mg/kg), and gross anatomy and histopathology observation were carried out after the continuous administration for 30 d and the recovery for four weeks. Results Some tissue structures of SD rats via 30 d successive administration, such as liver, kidney, spleen, and lymph node, were changed, such as hepatocyte acidophily change, part epithelial cell degeneration of renal tubule in the renal medulla, the increase of the number of lymphoid follicle and the volume of germinal center in lymph node, and the volume of germinal center and the boundary zone of white pulp in spleen. The reversablity of these changes except kidney is not obvious. Conclusion The liver, spleen, kidney, and lymph nod are injuried by trolamine via iv injection. The damage of kidney is reversible, but the damage of the liver, spleen and lymph nod could only be reversed partly.