目的 探討刺梨汁對(duì)環(huán)磷酰胺合并⁶⁰Co致骨髓抑制小鼠造血功能的影響，研究其促進(jìn)血細(xì)胞上調(diào)的作用機(jī)制。方法 雙抗體夾心法檢測(cè)外周血象、骨髓基質(zhì)中紅細(xì)胞生成素（EPO）、血小板生成素（TPO）、粒細(xì)胞生長(zhǎng)因子（GCSF）的量。結(jié)果 刺梨汁能明顯改善骨髓抑制小鼠外周血象；能有效平衡微環(huán)境中TPO的量；改善EPO的表達(dá)；對(duì)骨髓抑制小鼠骨髓細(xì)胞上清中GCSF有明顯的正調(diào)控作用。結(jié)論 刺梨汁能提高骨髓抑制小鼠外周血血細(xì)胞和骨髓有核細(xì)胞計(jì)數(shù)；可促進(jìn)骨髓抑制小鼠骨髓細(xì)胞從G₀/G₁期進(jìn)入增殖周期；并能有效調(diào)節(jié)骨髓微環(huán)境中TPO、EPO、GCSF的表達(dá)，從而促進(jìn)骨髓抑制小鼠的造血功能，可作為一種治療貧血的輔助保健藥物。

Objective To investigate the effect of Rosa roxburghii juice (RRJ) on the hematopoiesis in myelosuppressive mice induced by cyclophosphamide merged ⁶⁰Co and to study the mechanism for making blood cells upregulating. Methods The peripheral blood, bone marrow stromal erythropoietin (EPO), thrombopoietin (TPO), and granulocyte growth factor (GCSF) contents were detected by double antibody sandwich method. Results RRJ could significantly improve the peripheral blood of myelosuppressive mice, effectively balance the amount of TPO in the microenvironment, improve the expression of EPO, and significantly up-regulate GCSF in the supernatant of mouse bone marrow cells. Conclusion RRJ could increase the peripheral blood cells and bone marrow nucleated cells in myelosuppressive mice, promote the bone marrow cells in myelosuppressive mice from the G₀/G₁ into the proliferation cycle, effectively regulate the expressions of TPO, EPO, and GCSF in the bone marrow microenvironment, thereby promote the hematopoietic function of myelosuppressive mice, as a health drug for anemia.