57BL/KsJ db/db mice, and to lay the foundation for the application of db/db mice on hypoglycemic agents. Methods With db/db mice as model animals and db/m mice as control animals, the body weight, food intake, water intake, fasting blood glucose, normal diet blood glucose, glucose tolerance, and insulin tolerance of mice were determined. In the 14th week, glycated serum protein (GSP), triacylglycerol (TG), and total cholesterol (TC) of serum were determined. The liver, pancreas, abdominal fat, and other major tissues were taken for histopathological examination. Results Compared with the control group, the body weight, food intake, water intake, fasting glucose, and normal diet glucose of db/db mice were significantly increased; The blood sugar level was stable throughout the trial period; The glucose and insulin tolerances were abnormal; The sensitivity to exogenous insulin of db/db mice was significantly reduced. GSP, TG, and TC concentration and abdominal fat weight were all increased. There was vacuolar degeneration in varying degrees in liver tissue, and the volume of fat cells was increased. The cytoplasm of pancreatic islet cell was reduced and the vessels were dilated. Conclusion The early lipid metabolism of db/db mice is disordered, the blood sugar and blood lipids are significantly increased, the glucose and insulin tolerances are abnormal, and the blood glucose level is stable. So db/db mouse is an ideal model for the study on type 2 diabetes."/>

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首頁 > 過刊瀏覽>2013年第36卷第1期 >2013,36(1):8-12. DOI:10.7501/j.issn.1674-6376.2013.01.003
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基因缺陷型2型糖尿病模型動物db/db小鼠早期生物學(xué)特性研究

Research on early biological characteristics of gene defect type 2 diabetes model db/db mice

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