目的 探討柴青消癖膠囊對(duì)乳腺增生模型大鼠的治療作用及可能的作用機(jī)制。方法 清潔級(jí)SD大鼠70只，隨機(jī)分成7組：對(duì)照組，模型組，枸櫞酸他莫昔芬組，消乳散結(jié)膠囊組，柴青消癖膠囊低、中、高劑量（0.432、0.856、1.712 g/kg）組。5周后，測定乳頭直徑及高度、臟器指數(shù)、血清中孕激素（P）、雌激素（E₂）、泌乳素（PRL）、睪酮（T）水平及超氧歧化酶（SOD）、丙二醛（MDA）量，鏡下觀察乳腺組織病理形態(tài)學(xué)變化。結(jié)果 柴青消癖膠囊中、高劑量組能顯著減小大鼠乳頭直徑及高度；升高胸腺、脾指數(shù)，降低子宮、卵巢指數(shù)；能提高血清中P、E₂、PRL水平，降低T的量；可明顯增加血清中SOD活性，降低MDA水平。結(jié)論 柴青消癖膠囊對(duì)乳腺增生模型大鼠有顯著的治療作用，其作用機(jī)制可能與增強(qiáng)免疫力、調(diào)節(jié)血清中性激素水平及抗氧化作用有關(guān)。

Objective To investigate the therapeutic action of Chaiqing Xiaopi Capsule (CXC) on the hyperplasia of mammary gland (HMG) in rats and to analyze the possible mechanism in treating HMG. Methods Seventy clean Sprague-Dawley rats were divided into seven groups including control, model, tamoxifen citrate, Xiaoru Sanjie Capsule, low-, mid-, and high-dose CXC (0.433, 0.855, and 1.712 g/kg) groups. After treatment for five weeks, the height and diameter of nipple were measured, the viscera indexes and the levels of progestogen (P), estrogen (E₂), prolactin (PRL), testosterone (T), superoxide dismutase (SOD), and malondialdehyde (MDA) in serum were determined, and the pathologic changes in morphology of breast tissue in rats were observed by microscopy. Results The mid- and high-dose CXC could remarkably reduce the diameter and height of nipple, increase the coefficient of thymus and spleen, and decrease the coefficient of uterus and ovaries. It could also increase the levels of E₂, P, and PRL, decrease T level in serum, increase the SOD activity, and decrease the content of MDA. Conclusion CXC has obvious therapeutic effect on HMG in rats, and the mechanism may be related to enhancing immunity, regulating sex hormone level in serum, and antioxidation.

山西省科技攻關(guān)項(xiàng)目資助（20100322027）