目的 對大承氣湯包裝袋進(jìn)行安全性研究。方法 從煎液本身性質(zhì)，如煎液的穩(wěn)定性、pH值、灰分、重金屬、有效成分等方面，對煎液予以考察，并且對包裝袋吸附煎液有效成分、吸附量及包裝袋殘留物予以檢測，采用高效液相色譜法、氣相色譜法對中藥湯劑包裝袋予以分析。結(jié)果 大承氣湯經(jīng)過10 d低溫及常溫存放，湯劑性質(zhì)穩(wěn)定，產(chǎn)生沉淀較少，且pH值、灰分、重金屬、有效成分均沒有很大的變化，包裝袋對煎液吸附量較少，對煎液有效成分不會產(chǎn)生很大影響，包裝袋經(jīng)過高溫之后不會產(chǎn)生有害成分，且本身性質(zhì)穩(wěn)定，從不同角度予以分析，可以用于大承氣湯包裝。結(jié)論 通過對大承氣湯包裝袋予以分析，為中藥煎液包裝袋安全性研究提供依據(jù)。

Objective To study the safety of Dachengqi Decoction packaging pouches made by liquid medicine packaging composite membrane. Methods The decoction properties, such as decoction stability, pH value, ash content, heavy metal, and effective components, were investigated, and the effective components, adsorption content, and residues in the adsorption decoction in pouches were inspected using high performance liquid chromatography and gas chromatography. Results After 10 d stored at low and normal temperature, Dachengqi Decoction was stable in property with no significant change in pH value, ash content, heavy metal, and effective components, and produced less precipitation. With the less adsorption content of the decoction, the packaging pouches could hardly have any influence on the effective components in the decoction and they produced no harmful components after being treated with high temperature. Because of the stability of packaging pouches, they could be used for the packaging of Dachengqi Decoction. Conclusion The packaging pouches of Dachengqi Decoction are analysed, in the study which could provide the theoretical basis for the packaging pouches of decoction.

國家中管局行業(yè)專項(xiàng)（201007010-05）