甘草酸對出血性、缺血性或缺血-再灌注性腦損傷、缺血-再灌注性脊髓損傷以及化學(xué)品造成的神經(jīng)損傷有顯著的保護(hù)作用，也能改善腦缺血性癡呆大鼠的學(xué)習(xí)記憶功能。綜述了甘草酸、甘草次酸、甘草酸二銨、甘珀酸對腦損傷的保護(hù)作用以及改善學(xué)習(xí)記憶功能的藥理作用研究進(jìn)展。認(rèn)為甘草酸的腦保護(hù)作用可能是其抗炎、抗氧化、抗細(xì)胞凋亡、抗膽堿酯酶和溫和的糖皮質(zhì)激素樣作用等基本藥理作用綜合的結(jié)果。

Glycyrrhizic acid has significantly protective effects on hemorrhagic, ischemic, ischemic-reperfusion encephalic injury, ischemic-reperfusion spinal cord injury, and chemicals-induced neuron damage, and improves the performance of learning and memory of rats with ischemic dementia. In this paper, the advances in pharmacologic studies on glycyrrhizic acid, glycyrrhetinic acid, diammonium glycyrrhizinate, and carbenoxolone in the protection of encephalic injury and the improvement of memory are reviewed. It is suggested that the encephalic protection of glycyrrhizic acid is a comprehensive result of the basic actions with anti-inflammatory, anti-oxidative, anti-apoptosis, anti-cholinesterase, and moderate glucocorticoid-like effects.