3, EtOAc, n-BuOH, and H2O. The inhibition of the different fractions on tyrosinase was detected. UPLC-MS/MS was used to analyze and identify the active components in the fraction with the strongest inhibition. Molecular docking was used to predict the potential activity and enzymological method was used to validate their efficacy components. Results The chloroform fraction showed a strong inhibition on tyrosinase activity. The bioactivities had the relationship with six components, such as tanshinol and protocatechualdehyde, etc. Enzymological method showed the same results with the screening. Conclusion Tanshinol, protocatechualdehyde, and so on in S. Miltiorrhiza have the significant inhibition on tyrosinase."/>

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首頁 > 過刊瀏覽>2013年第36卷第2期 >2013,36(2):85-89. DOI:10.7501/j.issn.1674-6376.2013.02.002
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具有酪氨酸酶抑制活性的丹參有效成分篩選研究

Screening of active components in Salvia miltiorrhiza with inhibition on tyrosinase

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