目的 對(duì)狗皮膏的皮膚用藥安全性進(jìn)行評(píng)價(jià)研究。方法 取不同廠家樣品10批分別進(jìn)行家兔急性皮膚刺激性試驗(yàn)和豚鼠皮膚過敏性試驗(yàn)，同時(shí)采用原子吸收分光光度法測(cè)定給藥后家兔血鉛濃度的變化。結(jié)果 10批樣品中有7批出現(xiàn)皮膚刺激反應(yīng)，除A廠家1批為中度刺激性，其余為輕度刺激性；10批樣品均未見皮膚過敏反應(yīng)；狗皮膏連續(xù)給藥7 d后，給藥組的血鉛濃度與對(duì)照組相比差異有統(tǒng)計(jì)學(xué)意義（P＜0.01），連續(xù)給藥14 d后的血鉛濃度與連續(xù)給藥7 d相比差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。結(jié)論 狗皮膏引起皮膚刺激反應(yīng)的風(fēng)險(xiǎn)較大，且不同廠家間、廠內(nèi)批次間存在差異；久貼狗皮膏可引起血鉛升高，建議改善制劑以減輕不良反應(yīng)。

Objective To evaluate and study the safety of Goupi Gao (a traditional black plaster) on skin. Methods Acute dermal irritation test of rabbit and dermal sensitivity test of guinea pig was carried out using 10 batches of samples from different manufacturers. Atomic absorption spectrophotometry was used to detect the variation of blood lead concentration in rabbits. Results Dermal irritation in rabbits and dermal sensitivity in guinea pig were observed in seven among 10 batches of samples. One sample from A manufacturer showed moderate irritation, and others showed light irritation. No sample had the hypersensitive effect; After continuous administration for 7 d, the difference of blood lead concentration in Goupi Gao group showed the statistical significance compared with that in the control group (P < 0.01). After continuous administration for 14 d, the difference of blood lead concentration had the statistical significance compared with that for 7 d (P < 0.05). Conclusion The risk of the dermal irritation with the use of Goupi Gao is higher, while there are obvious differences among the products from different manufacturers or the different batches from the same manufacturer. Using Goupi Gao for a long time may induce high blood lead. It is suggested that the preparation should be readjusted for decreasing its adverse reactions.