目的 研究肉桂提取物醇質(zhì)體經(jīng)皮給藥系統(tǒng)中提高藥物滲透性的方法。方法 以水蒸汽蒸餾法提取肉桂油，注入法制備不同濃度醇質(zhì)體，以SD雄性大鼠皮膚作為媒介，F(xiàn)ranz單室擴(kuò)散池為體外模型，HPLC測定透過皮膚的肉桂酸含量。結(jié)果 相比于20%肉桂醇質(zhì)體，30%、40%和50%肉桂醇質(zhì)體分別增滲1.31、1.69和2.06倍。氮酮、丙二醇、氮酮＋丙二醇3組促滲劑相比于30%醇質(zhì)體，分別促滲2.31、1.10、3.40倍。醇質(zhì)體凝膠滲透速率大于30%醇質(zhì)體和凝膠。結(jié)論 提高醇濃度，加促滲劑，制備親水凝膠的藥劑學(xué)手段，能有效促進(jìn)肉桂提取物的經(jīng)皮滲透。

Objective To investigate the methods of enhancing the permeability in Cinnamon Cortex extract transdermal drug delivery system with ethosomes as a vector. Methods Cassia oil was extracted by steam distillation and injected into ethosomes with different concentration. The amount of cinnamic acid passing through the skin of SD male rats released from ethosomes was determined by HPLC under the model of Franz diffusion cells in vitro. Results Compared to CC, ethosome with 20% ethanol, the permeabilities of CC ethosomes with 30%, 40%, and 50% ethanol were increased by 1.31-, 1.69-, and 2.06-fold, respectively. Compared to CC ethosome with 30% ethanol, the permeabilities were increased by 2.31-, 1.10-, and 3.40-fold, with the penetration enhancer of Azone alone, propylene glycol alone or both, respectively. The permeability of CC ethosome gel was higher than that of CC ethosome and cassia oil gels. Conclusion The transdermal permeability of CC extract is enhanced by rising the concentration of ethanol, adding penetration enhancer, and preparing hydrogel.