目的 建立了祛毒清熱顆粒的質(zhì)量標(biāo)準(zhǔn)。方法 采用薄層色譜法對方中的連翹、柴胡、甘草、板藍根進行定性鑒別，采用高效液相色譜法對君藥虎杖中的大黃素進行了定量測定。結(jié)果 薄層分離度好，專屬性強；大黃素在0.064～0.512 μg內(nèi)與峰面積線性關(guān)系良好，平均回收率為99.03%，RSD值為0.23%（n＝9）。結(jié)論 所建立的方法準(zhǔn)確可靠，靈敏度高，專屬性強，可有效控制祛毒清熱顆粒的質(zhì)量。

Objective To establish the quality standard for Qudu Qingre Granule (QQG). Methods TLC method was performed to identify Forsythiae Fructus, Bupleuri Radix, Glycyrrhizae Radix et Rhizoma, and Isatidis Radix in QQG and HPLC was used to determine the content of emodin in sovereign medicine—Polygoni Cuspidati Rhizoma et Radix. Results TLC had good resolution and specificity. The emodin showed a good linear relationship within the range of 0.064 — 0.512 μg. The average recovery rate was 99.03% with RSD of 0.23% (n = 9). Conclusion The method is accurate, specific, and could be used for the quality control of QQG.