在慢性疾病過程中，免疫炎癥反應(yīng)的存在已是不可爭辯的事實，其在動脈粥樣硬化的整個發(fā)病過程中所發(fā)揮的重要作用也得到了廣泛的認(rèn)同。通過對國內(nèi)外有關(guān)動脈粥樣硬化炎癥機制方面的文獻整理，對慢性免疫炎癥在動脈粥樣硬化中的顯著作用有了更深入了解。重點綜述了巨噬細(xì)胞、樹突狀細(xì)胞等免疫細(xì)胞以及腫瘤壞死因子-α，單核細(xì)胞趨化因子-1和基質(zhì)金屬蛋白酶等炎癥因子致動脈粥樣硬化的發(fā)病機制，協(xié)同不同性質(zhì)的中藥對動脈粥樣硬化的干預(yù)作用，以期為治療動脈粥樣硬化提供參考。

Immune inflammatory reaction is widespread in the chronic diseases and affects deeply on atherosclerosis. Through researching the domestic and international paper on atherosclerosis inflammatory mechanisms, more in-depth understanding is achieved in the chronic immune inflammation in atherosclerosis. This paper reviews the macrophages, dendritic cells, tumor necrosis factor-α, monocyte chemotactic factors-1, and matrix metalloproteinase to study the pathogenesis of atherosclerosis. At the same time, researching the intervention effect of different kinds of Chinese materia medica on atherosclerosis, in order to further study the therapeutic mechanism of atherosclerosis inflammation.

國家自然基金青年科學(xué)基金（81102663）