在慢性疾病過(guò)程中，免疫炎癥反應(yīng)的存在已是不可爭(zhēng)辯的事實(shí)，其在動(dòng)脈粥樣硬化的整個(gè)發(fā)病過(guò)程中所發(fā)揮的重要作用也得到了廣泛的認(rèn)同。通過(guò)對(duì)國(guó)內(nèi)外有關(guān)動(dòng)脈粥樣硬化炎癥機(jī)制方面的文獻(xiàn)整理，對(duì)慢性免疫炎癥在動(dòng)脈粥樣硬化中的顯著作用有了更深入了解。重點(diǎn)綜述了巨噬細(xì)胞、樹(shù)突狀細(xì)胞等免疫細(xì)胞以及腫瘤壞死因子-α，單核細(xì)胞趨化因子-1和基質(zhì)金屬蛋白酶等炎癥因子致動(dòng)脈粥樣硬化的發(fā)病機(jī)制，協(xié)同不同性質(zhì)的中藥對(duì)動(dòng)脈粥樣硬化的干預(yù)作用，以期為治療動(dòng)脈粥樣硬化提供參考。

Immune inflammatory reaction is widespread in the chronic diseases and affects deeply on atherosclerosis. Through researching the domestic and international paper on atherosclerosis inflammatory mechanisms, more in-depth understanding is achieved in the chronic immune inflammation in atherosclerosis. This paper reviews the macrophages, dendritic cells, tumor necrosis factor-α, monocyte chemotactic factors-1, and matrix metalloproteinase to study the pathogenesis of atherosclerosis. At the same time, researching the intervention effect of different kinds of Chinese materia medica on atherosclerosis, in order to further study the therapeutic mechanism of atherosclerosis inflammation.

國(guó)家自然基金青年科學(xué)基金（81102663）