Chinese medicinal granules are products of the reformation of Chinese Traditional Medicine in the 1990s, with modern science and technology, according to certain production technology we make the Chinese Traditional Medicine into the granules products which are for use of clinical dispensing and which have the characteristics of easy to use and curative effect. The article expounds some of the research work of the quality control of Chinese medicinal granules in recent years, including thin-layer chromatography, high performance liquid chromatography (HPLC), infrared spectroscopy (IR), ultraviolet spectroscopy (UV), ultra-high performance liquid chromatography (UPLC), and gas chromatography - mass spectrometry technology (GC-MS); as well as gives examples to illustrate the specific application of quality control methods of Chinese medicinal granules.