目的 研究調(diào)經(jīng)補(bǔ)血丸的補(bǔ)血養(yǎng)血、理氣通經(jīng)及鎮(zhèn)痛作用。方法 采用大鼠氣滯血瘀模型、失血性血虛小鼠模型、縮宮素疼痛模型及縮宮素引起的大鼠子宮條收縮模型，考察調(diào)經(jīng)補(bǔ)血丸的藥理作用。結(jié)果 調(diào)經(jīng)補(bǔ)血丸在0.3～2.4 g/kg劑量下，ig給藥能夠非常顯著地降低氣滯血瘀模型大鼠的全血黏度和血漿黏度；能夠顯著增加失血性血虛小鼠紅細(xì)胞數(shù)量和血紅蛋白量；能夠顯著地減少縮宮素所致小鼠扭體次數(shù)；在終質(zhì)量濃度3.6×10^-5、1.2×10^?4、3.6×10^?4、1.2×10^?3 g/mL對縮宮素引起的大鼠子宮條收縮有非常顯著的拮抗作用。結(jié)論 調(diào)經(jīng)補(bǔ)血丸具有較好的活血化瘀、補(bǔ)血養(yǎng)血、理氣通經(jīng)及鎮(zhèn)痛作用。

Objective To investigate the function of Tiaojingbuxue Pill in nourishing blood, promoting menstruation by regulating Qi and analgesia. Methods The pharmacological action of Tiaojingbuxue Pill was observed by rats model of Qi- stagnation and blood stasis, hemorrhagic deficiency models of mice, oxytocin pain models, and uterine contraction models of rats induced by oxytocin. Results Tiaojingbuxue Pill (ig 0.3—2.4 g/kg) could significantly reduce the blood viscosity and plasma viscosity of rats with Qi- stagnation and blood stasis, also could markedly increase the amounts of erythrocyte and hemoglobin of mice with hemorrhagic anemia and lower the frequency of body-torsion of mice induced by oxytocin. Meanwhile, Tiaojingbuxue Pill (3.6 × 10^?5, 1.2 × 10^?4, 3.6 × 10^?4, and 1.2×10^?3 g/mL) had antagonistic action on uterine contraction of rats induced by oxytocin. Conclusion Tiaojingbuxue Pill has the significant effect of activating blood circulation to dissipate blood stasis, nourishing blood, promoting menstruation by regulating Qi and analgesia.