目的 初步評價小兒哮喘寧的平喘作用，為臨床應(yīng)用提供科學(xué)的實(shí)驗(yàn)依據(jù)。方法 運(yùn)用乙酰膽堿及組胺致豚鼠哮喘模型、內(nèi)毒素（lipoplysaccharides，LPS）致小鼠急性肺損傷模型、卵白蛋白（ovalbumin，OVA）致豚鼠過敏性哮喘模型及OVA加LPS致小鼠過敏性哮喘模型，評價小兒哮喘寧的平喘作用。結(jié)果 小兒哮喘寧20、10、5 g/kg均能延長乙酰膽堿＋組胺所致豚鼠化學(xué)刺激性哮喘的引喘潛伏期及OVA致豚鼠過敏性哮喘的引喘潛伏期并減少跌倒動物數(shù)；20 g/kg小兒哮喘寧能降低LPS致小鼠急性肺損傷程度；對嗜酸粒細(xì)胞（eosinophil，EOS）浸潤型過敏性哮喘動物模型的作用優(yōu)于對中性粒細(xì)胞（neutrophil，NEU）浸潤型過敏性哮喘動物模型的作用。結(jié)論 小兒哮喘寧有平喘的作用，該作用可能與其抑制肺水腫、降低氣道EOS浸潤有關(guān)。

Objective To investigate the antiasthmatic effect of Xiao’er Xiaochuanning and to provide the experimental evidence for its clinical application. Methods The acetylcholine and histamine-induced asthma model in guinea pigs, lipoplysaccharides (LPS)-induced acute lung injury model in mice, ovalbumin (OVA)-induced guinea pig allergic asthma model, and OVA + LPS-induced mice allergic asthma model were used to evaluate the antiasthmatic effect of Xiao’er Xiaochuanning. Results Xiao’er Xiaochuanning (20, 10, and 5 g/kg) prolonged the latent period in acetylcholine- and histamine-induced asthma of guinea pigs and OVA-induced allergic asthma of guinea pig, and could reduce the number of tumbling animals. Xiao’er Xiaochuanning (20 g/kg) could reduce the acute lung injury induced by LPS; However, the protective effect against OVA-induced eosinophilic (EOS) inflammation in guinea pigs was better than that of OVA + LPS-induced noneosinophilic (NEU) inflammation in mice. Conclusion The protection of Xiao’er Xiaochuanning against asthma is related to inhibiting the pulmonary edema and decreasing the eosinophilic infiltration in airway.

四川省公益性科研院所基本科研項(xiàng)目（A-2011N-8）