開發(fā)多藥耐藥腫瘤的細(xì)胞模型和動物模型對于其相關(guān)基礎(chǔ)研究和藥物評價意義重大。綜述了腫瘤多藥耐藥模型的建模方法，分別對細(xì)胞模型和荷瘤動物模型的建立類型、各自特點(diǎn)、評價手段及研究意義等進(jìn)行了分析和總結(jié)。為建立優(yōu)勢腫瘤多藥耐藥模型、優(yōu)化現(xiàn)有抗腫瘤藥物評價方法提供參考，有助于闡明多藥耐藥相關(guān)機(jī)制，并為臨床用藥提供指導(dǎo)。

This study intends to review the methods of building tumor multidrug resistance (MDR) models and animal model. The establishment methods, characteristics, evaluation tools, and the study significance of the models including MDR cells and MDR animals were analyzed and summarized. It could provide a reference to establish an advanced MDR model, and to optimize the evaluation model of antitumor drugs. It could also be helpful to clarify the mechanisms of MDR and may provide the guidance for the clinical usage of antitumor drugs.

國家自然科學(xué)基金（U1204830）；河南省教育廳科學(xué)技術(shù)研究重點(diǎn)項(xiàng)目資助計(jì)劃（13A310064）