Markov模型于20世紀80年代用于醫(yī)學領域，目前已成為藥物經(jīng)濟學評價中最常用的方法之一，且前景廣闊。國內利用Markov模型進行藥物經(jīng)濟學評價雖然相比于國外起步較晚，但發(fā)展速度不斷加快，差距日漸縮小，評價方案逐步實現(xiàn)正規(guī)化。查閱近5年國內外相關文獻，圍繞模型建立與參數(shù)設定、設立對照、不確定性分析以及評價結果這4個基本流程，簡述國內外學者利用Markov模型進行藥物經(jīng)濟學評價的研究進展，并指明該方法的不足之處。

The Markov model was used in the medicinal field in the 1980s. It has become one of the most commonly used method in pharmaco-economics and it also has broad prospects. The use of Markov model in pharmaco-economics in China started later than aboard. However, the pace of development continues to be accelerated and the gap is shrinking. The evaluation program is being gradually normalized. To search the related literature in the last five years and around modeling establishment, the parameter settings, the uncertainty analysis, and the evaluation results of these four basic processes, the research progress of domestic and foreign scholars who use Markov model for pharmaco-economics evaluation are summarized and the shortcomings of this method are indicated.