4)造模,每周2次。于60 d后,檢測大鼠血清丙氨酸氨基轉(zhuǎn)移酶(ALT)、天冬氨酸氨基轉(zhuǎn)移酶(AST)、總蛋白(TP)、白蛋白(ALB)、肝組織丙二醛(MDA)、谷胱甘肽過氧化物酶(GSH-Px)、羥脯氨酸(Hyp)及肝組織病理變化。結(jié)果 與模型組比較,毛菊苣提取物低、中、高劑量組均能明顯降低肝纖維化大鼠血清中ALT、AST的含量及肝組織中MDA和Hyp的含量(P<0.01),明顯提高血清TP、ALB水平(P<0.05、0.01)及肝組織GSH-Px活性(P<0.01);肝臟組織學(xué)檢查表明,毛菊苣提取物可明顯改善肝組織病理損傷程度,其作用呈一定的量效關(guān)系。結(jié)論 毛菊苣提取物對實驗性慢性肝損傷具有保護肝細胞,減少肝損傷,抗肝纖維化作用。;Objective To investigate the effects of Cichorium glandulolsum extract (CGE) on liver fibrosis induced by chronic hepatic injury. Methods Wistar rats were randomizedly divided into six groups: CGE (50, 100, and 150 mg/kg) treatment groups, colchicine (Colc, 0.5 mg/kg) treatment group, model group, and normal control group. Rats were sc injected with carbon tetrachloride (CCl4) two times a week to induce liver fibrosis as well as ig administration of CGE or Colc. After 60 d, the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein (TP), albumin (ALB) in serum and malondialdehyde (MDA), glutathione peroxidase (GSH-Px), hydroxyproline (Hyp) in liver tissue were determined, and the liver histological changes were investigated by pathological examination. Results Compared with the model group, CGE significantly reduced the levels of ALT and AST in serum (P < 0.01), and decreased MDA and Hyp levels in liver tissue (P < 0.01) while TP, ALB, and GSH-Px were significantly elevated (P < 0.05, 0.01). Pathological examination revealed that CGE had the therapeutical effect on the experimental liver fibrosis. Conclusion CGE has the better effects on protecting hepatocyte, relieving liver injury, and against liver fibrosis."/>

醉酒后少妇被疯狂内射视频,一本色道久久综合一,在线天堂新版资源www在线下载,中文字幕乱人伦高清视频,中字幕视频在线永久在线观看免费

首頁 > 過刊瀏覽>2013年第36卷第6期 >2013,36(6):418-421
上一篇 | 下一篇

毛菊苣提取物對四氯化碳誘導(dǎo)大鼠肝纖維化的防治作用

Preventive and therapeutic effects of Cichorium glandulolsum extract on carbon tetrachloride-induced liver fibrosis in rats

發(fā)布日期:2013-11-29
您是第位訪問者
藥物評價研究 ® 2025 版權(quán)所有
技術(shù)支持:北京勤云科技發(fā)展有限公司
津備案:津ICP備13000267號 互聯(lián)網(wǎng)藥品信息服務(wù)資格證書編號:(津)-非經(jīng)營性-2015-0031