目的 測(cè)定阿齊沙坦的油水分配系數(shù)。方法 配制不同pH值的磷酸鹽緩沖液，以正辛醇-磷酸鹽緩沖液作為分散系統(tǒng)，搖瓶法作為測(cè)定方法，照紫外-可見分光光度法（《中國(guó)藥典》2010年版附錄ⅣA）進(jìn)行測(cè)定。通過阿齊沙坦分配平衡后在油相（正辛醇）和水相的濃度比，計(jì)算油水分配系數(shù)。結(jié)果 在正辛醇-磷酸鹽緩沖液體系中，pH＝3.0時(shí)阿齊沙坦的油水分配系數(shù)為3.78，pH＝7.0時(shí)阿齊沙坦的油水分配系數(shù)為?0.30。結(jié)論 應(yīng)用搖瓶-紫外分光光度法，能夠準(zhǔn)確測(cè)定阿齊沙坦的油水分配系數(shù)，并由此推測(cè)其體內(nèi)過程。

Objective To determine the oil-water partition coefficient of Azilsartan. Methods A shake flask-ultraviolet spectrophotometry method was applied to determining the oil-water partition coefficient of Azilsartan in n-octanol-buffer solution systems with different pH values. Results The LgP of Azilsartan under pH 3.0 was 3.78 and pH 7.0 was ?0.30. Conclusion The shake flask-ultraviolet spectrophotometry method can be used to determine the oil-water partition coefficient of Azilsartan, and help to predict the in vivo process.