目的 觀察人參健心膠囊對胰島素抵抗（IR）大鼠內(nèi)皮的保護作用。方法 通過高脂膳食建立胰島素抵抗Wistar大鼠模型，分為人參健心膠囊高、低劑量組，二甲雙胍治療組，模型組，并設(shè)立正常對照組，療程6周。以李氏胰島素敏感指數(shù)（ISI）評價胰島素抵抗，對照各治療組與模型對照組內(nèi)皮素-1（ET-1）、一氧化氮（NO）指標，光鏡下觀察主動脈血管內(nèi)皮形態(tài)。結(jié)果 人參健心膠囊高、低劑量治療組和二甲雙胍治療組治療后胰島素水平明顯降低、胰島素敏感指數(shù)明顯升高，NO明顯升高，ET-1明顯降低。光鏡下觀察人參健心高劑量組、二甲雙胍組內(nèi)皮結(jié)構(gòu)基本正常，模型組內(nèi)皮損傷嚴重。結(jié)論 人參健心膠囊可以改善胰島素抵抗大鼠的胰島素抵抗狀態(tài)，對血管內(nèi)皮具有保護作用。

Objective To explore the protective effects of Renshen Jianxin Capsule (RJC) on the endothelium of rats with insulin resistance (IR). Methods The model of IR was established by feeding high fat laboratory diet. The model rats were divided into several groups: control, model, metformin, high- and low-dose RJC groups, six weeks as a course of treatment. IR was evaluated using Lee insulin sensitivity index (ISI), the levels of NO and endothelin-1 (ET-1) in blood were compared, and the endothelial cells in slice aortic arch were observed. Results In metformin, high- and low-dose RJC groups, the levels of insulin and ET-1 decreased, and the ISI and NO level increased significantly. The endothelium of slice aortic arch in the model group was hurt heavily, while the endothelium of high-dose RJC and metformin groups is generally normal. Conclusion RJC could improve IR and protect blood vessel endothelium.