目的 研究四逆散對蛋氨酸-膽堿缺乏（methionine-choline-deficient，MCD）飲食誘導(dǎo)的小鼠非酒精性脂肪肝炎的作用及機(jī)制。方法 通過MCD飲食誘導(dǎo)小鼠非酒精性脂肪肝炎模型，并同時預(yù)防性給藥普羅布考及四逆散4周，HE染色觀察各組小鼠肝組織病理改變；檢測小鼠血清丙氨酸氨基轉(zhuǎn)移酶（ALT）、門冬氨酸氨基轉(zhuǎn)移酶（AST）、三酰甘油（TG）、含量以及肝臟組織TG、丙二醛（MDA）含量和超氧化物歧化酶（SOD）活力。結(jié)果 四逆散高劑量組小鼠血清ALT、AST均有下降，血清中TG含量升高，且肝臟TG含量降低；病理觀察顯示四逆散高劑量組小鼠肝細(xì)胞內(nèi)脂肪空泡減少，炎性細(xì)胞浸潤減少；同時肝組織SOD活力增加，MDA含量降低。結(jié)論 高劑量四逆散對MCD飲食誘導(dǎo)的小鼠非酒精性脂肪肝炎有預(yù)防作用，其主要通過調(diào)節(jié)血清和肝臟TG的分布，增加肝組織抗氧化能力，減少體內(nèi)過氧化物損害來實(shí)現(xiàn)。

Objective To study the effect of Sini Powder on non-alcoholic fatty hepatocirrhosis (NASH) induced by methionine- choline deficit (MCD) diet. Methods The model mice of NASH were administered with probucol and Sini Powder for 4 weeks. Then the pathological changes of liver were observed by HE staining, the contents of ALT, AST, TG, and MDA and the activity of SOD were tested and compared among groups. Results Compared with the model group, the ALT and AST contents in serum were lower, TG content in serum was reduced, and TG content in liver was higher in high-dose Sini Powder group. The pathological observation showed that the lipo-vacuoles were reduced in hepatocytes, and the infiltration of inflammatory cell was decreased. The activity of SOD was increased while the content of MDA was decreased. Conclusion High-dose Sini Powder can prevent the course of NASH induced by MDC diet by adjusting TG distribution in serum and liver, increasing the anti-oxidative capacity of liver, and reducing the peroxide damage.