女貞子具有保肝的藥理作用，已經(jīng)證實齊墩果酸、紅景天苷、女貞子多糖等化合物是其保肝的有效成分。女貞子提取物及其有效成分能對抗多種化學(xué)性肝損傷、對抗免疫性或缺血再灌注性肝損傷以及抗肝纖維化，其中齊墩果酸的保肝作用被研究得最為廣泛而深入；抗氧化應(yīng)激、抗炎、抑制肝星狀細(xì)胞增殖和活化、促進其凋亡以及肝細(xì)胞再生可能是它們共同的保肝機制。綜述了女貞子粗提物、女貞子多糖和紅景天苷保肝作用的研究進展。

Ligustri Lucidi Fructus has hepatoprotective effect. It has confirmed that oleanolic acid, salidroside, and polysaccharides are hepatoprotective constituents of Ligustri Lucidi Fructus. The extracts and active constituents from Ligustri Lucidi Fructus counteract many chemicals-induced liver injuries, immunological liver injury, hepatic ischemic/reperfusion injury, and liver fibrosis. Therein the hepatoprotective effect of oleanolic acid is studied most extensively and deeply. Anti-oxidative stress, anti-inflammation, inhibition on the proliferation and activation of hepatic stellate cells, promoting apoptosis of hepatic stellate cells, and hepatocyte regeneration may be their common hepatoprotective mechanism. This paper reviews the research advances on hepatoprotective effects of crude extracts from Ligustri Lucidi Fructus, polysaccharides from Ligustri Lucidi Fructus, and salidroside.