相對于藥物安全性評價的臨床研究,實驗動物的臨床檢驗指標存在一定的特殊性,應(yīng)結(jié)合受試藥物、動物表現(xiàn)、其他實驗結(jié)果及其他檢測結(jié)果進行綜合分析。結(jié)合相關(guān)理論及筆者的實踐經(jīng)驗對這個問題進行簡要分析與討論,主要內(nèi)容包括建立實驗室的正常參考值、如何排除非受試物因素對檢驗結(jié)果的影響、對結(jié)果的統(tǒng)計分析等綜合分析的前提、綜合分析的總體思路與方法、如何對血液學指標、血液生化學指標及凝血指標進行具體分析。

There is a certain particularity in animal examinations comparing with clinical examinations. We should analyse comprehensively combining article, symptoms and signs of animal, the result of other test and determination. In this paper, we discuss this issue by combining the theory and our experience in clinical pathology. The main content is to establish the animal's normal reference values, how to exclude the effect of other factor on the clinical examination. On the statistic analysis of result, specific analysis idea and method of hematology, blood biochemistry, and blood clotting are reviewed.