胚胎干細(xì)胞是從早期胚胎或原始性腺分離后能在體外長(zhǎng)期傳代培養(yǎng)的全能細(xì)胞系。胚胎干細(xì)胞體外可以誘導(dǎo)分化為各種體細(xì)胞,并且用這些體細(xì)胞治療相應(yīng)的疾病,一直以來(lái)是生物醫(yī)藥領(lǐng)域的研究焦點(diǎn)。目前,在該領(lǐng)域用于誘導(dǎo)胚胎干細(xì)胞分化的方法很多,其中的一些方法就用到化合物和部分中藥提取物。整理近5年來(lái)胚胎干細(xì)胞體外通過(guò)擬胚體途徑、細(xì)胞單層誘導(dǎo)分化為肝細(xì)胞和心肌細(xì)胞的有關(guān)文獻(xiàn),做一簡(jiǎn)要綜述。

Embryonic stem cell, separated from the early embryo or the original gonad, is the all-around cell line, which can be well for long-term passages in vitro. Embryonic stem cells can be differentiated into all kinds of somatic cells in vitro and are used to heal relevant serious illnesses. It is a hot spot in the field of study on the embryonic stem cell. It is difficult to find the mechanism, although it is very important. Currently, there are a lot of methods used to induce embryonic stem cells, and some of which are used for the compounds and parts of traditional Chinese medicine extracts. The author has compiled the nearly five years' literature on embryonic stem cells differentiating into myocardial cells and liver cells and reviewed to provide the reference.

“重大新藥創(chuàng)制”科技重大專(zhuān)項(xiàng)(2012XZ09505);973計(jì)劃資助(2010CB735602);“十一五”國(guó)家科技支撐計(jì)劃(2007BAI41B03)