胚胎干細胞是從早期胚胎或原始性腺分離后能在體外長期傳代培養(yǎng)的全能細胞系。胚胎干細胞體外可以誘導(dǎo)分化為各種體細胞,并且用這些體細胞治療相應(yīng)的疾病,一直以來是生物醫(yī)藥領(lǐng)域的研究焦點。目前,在該領(lǐng)域用于誘導(dǎo)胚胎干細胞分化的方法很多,其中的一些方法就用到化合物和部分中藥提取物。整理近5年來胚胎干細胞體外通過擬胚體途徑、細胞單層誘導(dǎo)分化為肝細胞和心肌細胞的有關(guān)文獻,做一簡要綜述。

Embryonic stem cell, separated from the early embryo or the original gonad, is the all-around cell line, which can be well for long-term passages in vitro. Embryonic stem cells can be differentiated into all kinds of somatic cells in vitro and are used to heal relevant serious illnesses. It is a hot spot in the field of study on the embryonic stem cell. It is difficult to find the mechanism, although it is very important. Currently, there are a lot of methods used to induce embryonic stem cells, and some of which are used for the compounds and parts of traditional Chinese medicine extracts. The author has compiled the nearly five years' literature on embryonic stem cells differentiating into myocardial cells and liver cells and reviewed to provide the reference.

“重大新藥創(chuàng)制”科技重大專項(2012XZ09505);973計劃資助(2010CB735602);“十一五”國家科技支撐計劃(2007BAI41B03)