替莫唑胺是一種新型口服化療藥,它被廣泛用于治療惡性腦膠質瘤。多形性膠質母細胞瘤是IV級腦腫瘤,由異質群體的細胞所組成,具有高度的滲透性,血管生成性及對化學治療的耐藥性等特點。目前標準的治療方案為術后切除放化療,但由于替莫唑胺的耐藥性,治療后只能為患者提供12~14個月的生存期?？偨Y了有關耐藥的幾種DNA修復機制及其他相關因素,揭示了一些導致替莫唑胺耐藥的分子機制及一些可能的治療新靶點,同時討論了一些可能的解決方法。

Temozolomide (TMZ) is a new oral chemotherapy agent to be approved for the treatment of high-grade malignant gliomas. Glioblastoma multiform (GBM) is a grade IV brain tumor characterized by a heterogeneous population of cells that are highly infiltrative, angiogenic, and resistant to chemotherapy. The current standard of care, comprised of surgical resection followed by radiation and the chemotherapeutic agent TMZ, only provides the patients with a 12—14 month survival period post-diagnosis. In this review we will describe several DNA repairing mechanisms of drug resistance and other relevant factors. Revealing a growing number of molecular mechanisms contributing to TMZ resistance and a broad range of potentially novel targets for therapy, at the same time we discuss some possible solution.