目的 通過抗驚厥和解熱實(shí)驗(yàn),研究山羊角對羚羊角的替代比例范圍,為山羊角替代羚羊角的應(yīng)用提供依據(jù).方法 采用戊四唑致小鼠驚厥實(shí)驗(yàn),觀察兩者對驚厥時(shí)間和死亡率的影響,并分別作量效關(guān)系圖;采用干酵母致大鼠發(fā)熱實(shí)驗(yàn),比較兩者對大鼠溫度升高的抑制作用,并分別作量效關(guān)系圖.結(jié)果 羚羊角能延長小鼠驚厥的潛伏期,降低死亡率;羚羊角和山羊角能不同程度地抑制大鼠體溫的升高.兩模型的替代比例分別為6.0:1與7.2:1.結(jié)論 山羊角替代羚羊角的比例范圍為(6.0:1～7.2:1).

Objective To provide the basis for application that replacement ratio range between horns of Capra hirus and horns of Saiga tataria, anticonvulsants and antipyretic experiment were arranged. Methods Anticonvulsants experiment induced by pentylenetetrazole in mice was arranged to observe the effects of two drugs on convulsion time and mortality, and respectively concentration-response relationship diagram was drawn. Antipyretic experiment induced by yeast was arranged to observe the inhibition of rapid temperature rise of two drugs, and concentration-response relationship diagram was drawn respectively. Results Horns of Saiga tataria can extend the latent period of convulsion and reduce the mortality rate; Horns of Capra hirus can inhibit the rising of body temperature in different degrees. Two models of replacement ratio were 6.0:1 and 7.2:1, respectively. Conclusion The ratio range of horns of Capra hirus instead of horns of Saiga tataria is 6.0:1—7.2:1.