目的 研究鹽酸伊伐布雷定對單硝酸異山梨酯在比格犬體內(nèi)的藥動學(xué)影響.方法 采用HPLC法測定單硝酸異山梨酯單獨給藥或聯(lián)合鹽酸伊伐布雷定給藥后不同時間比格犬體內(nèi)的血藥濃度,采用非房室模型計算單硝酸異山梨酯藥動學(xué)參數(shù).結(jié)果 單硝酸異山梨酯單獨給藥及與鹽酸伊伐布雷定聯(lián)合使用后,在比格犬體內(nèi)單硝酸異山梨酯的主要藥動學(xué)參數(shù)差異無統(tǒng)計學(xué)意義(P<0.05).單硝酸異山梨酯聯(lián)合鹽酸伊伐布雷定給藥相對單硝酸異山梨酯單獨給藥的生物利用度為100%.結(jié)論 鹽酸伊伐布雷定與單硝酸異山梨酯聯(lián)合用藥后對單硝酸異山梨酯在比格犬體內(nèi)的藥動學(xué)過程無影響.

Objective To study the effect of Ivabradine on isosorbide-5-mononitrate (5-ISMN) pharmacokinetics in Beagle's dogs. Methods The plasma concentration of 5-ISMN was determined by HPLC after taking single or combined Ivabradine administration in Beagle's dogs. The pharmacokinetics parameters of 5-ISMN were calculated using the non-compartmental analysis. Results Non-statistically significant differences have been observed for the main pharmacokinetic parameters of 5-ISMN when administered alone or with Ivabradine (P < 0.05). Compared with single drug administration, the relative bioavailability of 5-ISMN administered with Ivabradine was 100%. Conclusion There is no effect of 5-ISMN combined with Ivabradine on pharmacokinetics of 5-ISMN in Beagle's dogs.