目的 探討通竅活血湯聯(lián)合窄譜中波紫外線治療扁平苔癬的效果.方法 口腔扁平苔癬患者64例按就診順序單雙號分為治療組與對照組各32例,兩組都給予窄譜中波紫外線治療,治療組在對照組治療的基礎上給予通竅活血湯治療,均治療15 d.觀察兩組的治療總有效率、不良反應與復發(fā)情況,同時對治療前后的血漿黏度進行檢測.結(jié)果 治療組的總有效率為100.0%,對照組總有效率為87.5%,治療組的總有效率明顯高于對照組(P<0.05).兩組治療期間皮膚過敏、胃腸癥狀、尿潴留、精神癥狀等不良反應發(fā)生情況對比差異無統(tǒng)計學意義,對癥處理后均明顯好轉(zhuǎn).治療后兩組的血漿黏度都呈現(xiàn)明顯下降趨勢(P<0.05),同時治療后治療組的血漿黏度明顯低于對照組(P<0.05);兩組不同時間點的紅細胞壓積對比差異無統(tǒng)計學意義.治療后6個月進行電話隨訪,治療組的復發(fā)率為0,對照組復發(fā)率為12.5%,治療組的復發(fā)率明顯低于對照組(P<0.05).結(jié)論 通竅活血湯聯(lián)合窄譜中波紫外線治療扁平苔癬能有效降低血漿黏度,從而提高治療療效,減少復發(fā),安全性也比較好,值得推廣應用.

Objective To investigate the effects of Tongqiao Huoxue Decoction (THD) combined with narrow band UVB for treating lichen planus. Methods Lichen planus patients (64 cases) were equally divided into treatment and the control groups based on the odd and even order numbers. The patients in both groups were given narrow band UVB therapy, the patients in treatment group received THD for treatment, and all patients were treated for 15 d. The total efficiency, adverse reactions, and relapse were observed, while the plasma viscosity before and after treatment was detected. Results The total efficiency in the treatment group was 100.0%, and that in the control group was 87.5%. The total efficiency in the treatment group was significantly higher (P < 0.05). During the treatment, the adverse reactions of skin allergies, gastrointestinal symptoms, urinary retention, and psychiatric symptoms in the two groups had no statistically significant differences and all were significantly improved after symptomatic treatment. After treatment, the plasma viscosity showed clear downward trend (P < 0.05), while the plasma viscosity after treatment in the treatment group were significantly lower than that in the control group (P < 0.05); The hematocrit values in two groups at different time were not significantly different. Through telephone followed-up after 6 months of treatment, the recurrence rate in the treatment group was 0.0%, and that in the control group was 12.5%. The recurrence rate in the treatment group was significantly lower than that in the control group (P < 0.05). Conclusion THD combined with narrow band UVB for treating lichen planus can effectively reduce plasma viscosity, thereby enhance the therapeutic efficacy and reduce recurrence, and its security is relatively good that should be widely applied.