目的 探討通竅活血湯聯(lián)合窄譜中波紫外線治療扁平苔癬的效果.方法 口腔扁平苔癬患者64例按就診順序單雙號(hào)分為治療組與對(duì)照組各32例,兩組都給予窄譜中波紫外線治療,治療組在對(duì)照組治療的基礎(chǔ)上給予通竅活血湯治療,均治療15 d.觀察兩組的治療總有效率、不良反應(yīng)與復(fù)發(fā)情況,同時(shí)對(duì)治療前后的血漿黏度進(jìn)行檢測(cè).結(jié)果 治療組的總有效率為100.0%,對(duì)照組總有效率為87.5%,治療組的總有效率明顯高于對(duì)照組(P<0.05).兩組治療期間皮膚過(guò)敏、胃腸癥狀、尿潴留、精神癥狀等不良反應(yīng)發(fā)生情況對(duì)比差異無(wú)統(tǒng)計(jì)學(xué)意義,對(duì)癥處理后均明顯好轉(zhuǎn).治療后兩組的血漿黏度都呈現(xiàn)明顯下降趨勢(shì)(P<0.05),同時(shí)治療后治療組的血漿黏度明顯低于對(duì)照組(P<0.05);兩組不同時(shí)間點(diǎn)的紅細(xì)胞壓積對(duì)比差異無(wú)統(tǒng)計(jì)學(xué)意義.治療后6個(gè)月進(jìn)行電話隨訪,治療組的復(fù)發(fā)率為0,對(duì)照組復(fù)發(fā)率為12.5%,治療組的復(fù)發(fā)率明顯低于對(duì)照組(P<0.05).結(jié)論 通竅活血湯聯(lián)合窄譜中波紫外線治療扁平苔癬能有效降低血漿黏度,從而提高治療療效,減少?gòu)?fù)發(fā),安全性也比較好,值得推廣應(yīng)用.

Objective To investigate the effects of Tongqiao Huoxue Decoction (THD) combined with narrow band UVB for treating lichen planus. Methods Lichen planus patients (64 cases) were equally divided into treatment and the control groups based on the odd and even order numbers. The patients in both groups were given narrow band UVB therapy, the patients in treatment group received THD for treatment, and all patients were treated for 15 d. The total efficiency, adverse reactions, and relapse were observed, while the plasma viscosity before and after treatment was detected. Results The total efficiency in the treatment group was 100.0%, and that in the control group was 87.5%. The total efficiency in the treatment group was significantly higher (P < 0.05). During the treatment, the adverse reactions of skin allergies, gastrointestinal symptoms, urinary retention, and psychiatric symptoms in the two groups had no statistically significant differences and all were significantly improved after symptomatic treatment. After treatment, the plasma viscosity showed clear downward trend (P < 0.05), while the plasma viscosity after treatment in the treatment group were significantly lower than that in the control group (P < 0.05); The hematocrit values in two groups at different time were not significantly different. Through telephone followed-up after 6 months of treatment, the recurrence rate in the treatment group was 0.0%, and that in the control group was 12.5%. The recurrence rate in the treatment group was significantly lower than that in the control group (P < 0.05). Conclusion THD combined with narrow band UVB for treating lichen planus can effectively reduce plasma viscosity, thereby enhance the therapeutic efficacy and reduce recurrence, and its security is relatively good that should be widely applied.