目的 觀察血必凈注射液對經(jīng)皮腎鏡碎石術(shù)(PCN)后全身炎癥反應(yīng)綜合征(SIRS)的治療效果。方法 PCN術(shù)后并發(fā)SIRS患者58例, 按隨機數(shù)字表法分為常規(guī)治療組(28例)和血必凈組(30例)。常規(guī)治療組患者給予左氧氟沙星注射液300 mg靜脈滴注, 2次/d;血必凈組在對照組的基礎(chǔ)上加用血必凈注射液50 mL+0.9氯化鈉注射液100 mL靜脈滴注, 2次/d。兩組患者均治療14 d。常規(guī)監(jiān)測患者的心率(HR)、呼吸頻率(RR)、體溫(T)、白細胞計數(shù)(WBC)以及SIRS及其癥狀改善時間, 并觀察兩組患者第1天和第14天血清中TNF-α、IL-6濃度變化。結(jié)果 常規(guī)治療組和血必凈組的臨床有效率分別為46.43%和76.67%, 兩組比較差異具有顯著性(P<0.05)。治療后HR、RR、T、WBC均有改善, 與治療前相比差異顯著(P<0.05), 但兩組間各項指標(biāo)差異均無顯著性。血必凈組HR、RR、T、WBC恢復(fù)時間明顯優(yōu)于常規(guī)治療組(P<0.05)。治療后兩組患者TNF-α、IL-6均得到明顯改善(P<0.05), 且兩組間比較有顯著性差異, 血必凈組優(yōu)于常規(guī)治療組(P<0.05)。結(jié)論 血必凈注射液能有效抑制PCN術(shù)后過激炎癥反應(yīng), 明顯改善SIRS癥狀。

Objective To observe the effects of Xuebijing Injection on the treatment results of systemic inflammatory response syndrome (SIRS) induced by undergoing percutaneous nephrolithotomy (PCN). Methods The 58 cases with SIRS induced by PCN in the Department of Urology Surgery, Haikou People's Hospital from September 2012 to October 2013 were randomly divided into conventional therapy group (28 cases) and Xuebijing Injection Group (30 patients) by digital table method. The patients in the control group were treated with iv infusion of Levofloxacin Injection 300 mg, 2 times/d; The patients in the Xuebijing Injection group on the basis of the control treatment group were added Xuebijing Injection 50 mL + 0.9 sodium chloride injection by iv infusion of 100 mL, 2 times/d. The patients in the two groups were treated in 14 d, the changes of serum concentrations of TNF-α, IL-6 between the two groups were obserbed on day 1, 3, 5, and 7, and heart rate (HR), respiratory rate (RR), temperature (t), white blood cell count (WBC), and SIRS symptom improvement time were routinely monitored. Results The clinical efficiencies of the conventional therapy and Xuebijing Injection are 46.43% and 76.67%, respectively. After statistical analysis, the statistical difference (P < 0.05) between the two groups was significant. Conclusion Xuebijing Injection could effectively inhibit the PCN-induced excessive inflammation after surgery and significantly improve the symptoms of SIRS.