益母草是一種活血化瘀的常用藥, 臨床上常用于治療月經(jīng)不調、產(chǎn)后瘀痛、心血管疾病、血液病等。益母草中含有生物堿、二萜、阿魏酸、揮發(fā)油、黃酮類、多糖等多種化學成分, 其中發(fā)現(xiàn)生物堿類、二萜類、環(huán)形多肽類等與益母草活血化瘀作用相關;其藥理作用與改變血液流變學, 改善微循環(huán), 改善心肌缺血, 抗血栓等有關。綜述益母草活血化瘀作用的物質基礎與作用機制研究進展, 旨在促進對該中藥的進一步研究, 為新藥研發(fā)提供依據(jù)。

Leonurus japonicus is a common drug used in activating blood and resolving stasis, clinically used to treat irregular menstruation, postpartum blood stasis pain, cardiovascular disease, blood disease, etc. There are alkaloids, diterpene, ferulic acid, volatile oil, flavonoid, polysaccharide, and other chemical components in L. japonicus. Researchers found that alkaloids, diterpenoid, and circular peptide are associated with blood circulation of L. japonicus; The pharmacological effects are related to changing blood rheology, improving microcirculation, improving myocardial ischemia, anti-platelet aggregation, and so on. Overviewing the research progress on the material basis and its mechanism of activating blood and resolving stasis. This paper aims at promoting the further research and development of Chinese materia medicaand providing the basis for the new drug research and development.

國家自然科學基金資助項目(81303209)