目的 探討血清β-人絨毛膜促性激素(β-HCG)與孕酮(P)動(dòng)態(tài)監(jiān)測(cè)對(duì)早孕期先兆流產(chǎn)的預(yù)測(cè)價(jià)值,為臨床診斷治療提供參考。方法 選取2011年9月-2013年8月收治的早孕期先兆流產(chǎn)孕婦178例作為研究對(duì)象,采用im HCG和黃體酮治療后,根據(jù)妊娠結(jié)局分為安胎組(n＝132)和流產(chǎn)組(n＝46),比較兩組治療前血清β-HCG、P水平及動(dòng)態(tài)監(jiān)測(cè)治療過(guò)程中血清β-HCG、P的變化情況。結(jié)果 安胎組入院時(shí)檢測(cè)β-HCG≥2 000 IU/mL者占比高達(dá)95.45%,而流產(chǎn)組僅有17.39%,兩組差異有統(tǒng)計(jì)學(xué)意義(P<0.001),安胎組入院時(shí)檢測(cè)未出現(xiàn)P水平<15 nmol/L者,而流產(chǎn)組出現(xiàn)P水平<15 nmol/L者占比高達(dá)73.91%,兩組差異有統(tǒng)計(jì)學(xué)意義(P<0.001);動(dòng)態(tài)監(jiān)測(cè)安胎組血清β-HCG、P呈上升趨勢(shì),且β-HCG的增幅較大;流產(chǎn)組血清β-HCG、P呈下降或微弱增長(zhǎng)的趨勢(shì),兩組患者血清β-HCG、P變化差異對(duì)比有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 動(dòng)態(tài)監(jiān)測(cè)早孕期先兆流產(chǎn)血清β-HCG與P水平可作為妊娠結(jié)局預(yù)后的重要指標(biāo)。

Objective To investigate the forecast value of dynamic monitoring of serum beta human chorionic gonadotropin (β-HCG) and progesterone (P) value on early threatened abortion, and to provide reference for clinical diagnosis and treatment. Methods Pregnant women (178 cases) during the first trimester threatened abortion from September, 2011 to August, 2013 were as the research object, and im injected with HCG and progesterone treatment. According to the outcome of pregnancy, they were divided into test group (n = 132) and abortion group (n = 46). The changes of β-HCG and P content between the two groups before treatment were recorded, and the serum β-HCG, and P content were dynamic monitored in the course of treatment. Results The occupancy rate detecting β-HCG ≥ 2 000 IU/mL of test group was high as 95.45%, while that of the abortion group accounted for only 17.39%, with significant difference between two groups (P < 0.001). There were no case detecting P < 15 nmol/L in test group, while the occupancy rate detecting P < 15 nmol/L in abortion group was high as 73.91%, with statistically significant difference between two groups (P < 0.001). The dynamic monitoring of serum β-HCG and P showed the trend of escalation, and β-HCG increased significantly in test group, while in abortion group the trend of serum β-HCG and P was declined or weak increase, with statistical significance (P < 0.05). Conclusion Dynamic monitoring of serum β-HCG and P levels in threatened abortion in early pregnancy can be used as an important index for prognosis of pregnancy.