目的 考察參葛定渴片對(duì)2型糖尿病大鼠糖代謝的調(diào)節(jié)作用.方法 采用ig高脂高糖脂肪乳加ip小劑量鏈脲佐菌素(STZ)的方法,建立2型糖尿病大鼠模型.將造模成功的大鼠隨機(jī)分為模型組、陽(yáng)性組和參葛定渴片高、中、低劑量組.實(shí)驗(yàn)各組均連續(xù)給藥4周.同時(shí)取健康大鼠為對(duì)照組,觀察各組大鼠行為學(xué)指標(biāo),檢測(cè)其血糖、糖耐量、血清胰島素水平.結(jié)果 與對(duì)照組比較,模型組體質(zhì)量下降,血糖值顯著升高、糖耐量能力降低以及血清胰島素水平升高.與模型組比較,陽(yáng)性組和參葛定渴片高、中劑量組可顯著降低糖尿病大鼠的血糖和血清胰島素水平(P <0.001、0.01),且參葛定渴片高劑量組可改善糖尿病大鼠的糖耐量(P <0.01).結(jié)論 參葛定渴片對(duì)2型糖尿病大鼠的糖代謝具有調(diào)節(jié)作用,可改善糖尿病大鼠的胰島素抵抗?fàn)顟B(tài).

Objective To study the effect of Shenge Tablets on glycometabolism of type 2 diabetic rats. Methods Type 2 diabetic rats were established by feeding high glucose and lipoids food and injecting small dose of streptozotocin. Then the models were randomized into model group, positive control group, and low-, mid-, high-dose Shenge Tablets groups. The rats in each group was administered by ig gavage for 30 d, then, their behavior, blood glucose, sugar tolerance, and serum insulin were detected. Results Compared with the normal control group, the body weight and the levels of blood glucose, sugar tolerance, and serum insulin of model group showed significant differences (P <0.001). Compared with the model group, the levels of blood glucose, serum insulin of positive control group, mid- and high-dose Shenge Tablets groups were significantly decreased (P <0.001, 0.01); The level of sugar tolerance of large dose group was significantly decreased (P <0.01). Conclusion Shenge Tablets can effectively regulate the glycometabolism of type 2 diabetic rats and improve their insulin resistance.

黑龍江省教育廳科學(xué)技術(shù)研究項(xiàng)目(編號(hào)11531338)