TM BEH C18(50 mm×2.1 mm,1.7 μm)色譜柱,流動相為甲醇-0.1%甲酸溶液(60:40);Waters Quattro Premier XE QQQ質(zhì)譜儀,離子源為ESI,檢測模式為正離子.結(jié)果 所有雜質(zhì)均以丁苯酞的質(zhì)譜裂解途徑為模板,進(jìn)行了質(zhì)譜解析,共確證了3個雜質(zhì)的化學(xué)結(jié)構(gòu).結(jié)論 該研究對于丁苯酞原料藥的雜質(zhì)分析、質(zhì)量控制和合成工藝的改進(jìn)具有重要作用.;Objective Investigation of butylphthalide and its related substances was carried out using a reversed phase ultra performance liquid chromatography/tandem mass spectrometry method. Methods Separation was performed on Waters ACQUITY UPLCTM BEH C18 (2.1 mm × 50 mm, 1.7 μm), the mobile phase consisted of methanol-0.1% formic acid in water (60:40); The identification of impurities in butylphthalide was performed with a triple-quadrupole mass spectrometer, with an electrospray ionization (ESI) source in the positive ion mode. Results All the impurities were deduced based on the MS fragment pathways of butylphthalide, a total of three compounds were characterized. Conclusion This work provides useful information for studying the origin of the impurities of butylphthalide and quality control of butylphthalide."/>

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首頁 > 過刊瀏覽>2015年第38卷第5期 >2015,38(5):516-519. DOI:10.7501/j.issn.1674-6376.2015.05.010
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UPLC-MS/MS法研究丁苯酞原料藥的雜質(zhì)譜

Study on impurity profiling of butylphthalide by UPLC-MS/MS

發(fā)布日期:2015-09-29
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